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Roxithromycin Capsules
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Roxithromycin Capsules

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Roxithromycin Capsule Instructions
Please read the instructions carefully and use under the guidance of a doctor
 
 
 
【Drug Name】
Generic name: Roxithromycin Capsules
English name: Roxithromycin Capsules
Chinese Pinyin: Luohongmeisu Jiaonang
【Ingredients】
Chemical name: 9-{O-[(2-methoxyethoxy)-methyl]oxime}erythromycin
Chemical Structure:
 
 
【Properties】
This product is a capsule, and the content is white or off-white powder and granules.
【Indications】 
This product is suitable for pharyngitis and tonsillitis caused by Streptococcus pyogenes, sinusitis, otitis media, acute bronchitis, chronic bronchitis caused by sensitive bacteria, pneumonia caused by Mycoplasma pneumoniae or Chlamydia pneumonia; Urethra caused by Chlamydia trachomatis Inflammation and cervicitis; skin and soft tissue infections caused by sensitive bacteria.
【specification】
75mg
【Dosage】
Oral on an empty stomach, the general course of treatment is 5-12 days.
Adults: 150mg once, twice a day; 300mg once, once a day.
Children weigh 2.5~5mg/kg once, twice a day.
【Adverse reactions】
The main adverse reactions are gastrointestinal reactions such as abdominal pain, diarrhea, nausea, and vomiting, but the incidence is significantly lower than that of erythromycin. Occasionally, skin rash, itching, dizziness, headache, abnormal liver function (increased ALT and AST), and decreased peripheral blood cells are common.
【Taboo】
People who are allergic to this product, erythromycin or other macrolide drugs should not be used.
【Precautions】
1. Use with caution in patients with liver dysfunction. In patients with severe liver cirrhosis, the blood elimination half-life (t1/2β) is extended to twice the normal level
For the above, if you really need to use it, 150 mg is administered once a day.
2. There is no need to adjust the dose for patients with mild renal insufficiency. For severe renal insufficiency, the administration time will be doubled (150 mg once a day, once a day).
3. There is cross-resistance between this product and erythromycin.
4. In order to obtain a higher blood concentration, this product needs to be taken with water on an empty stomach (1 hour before a meal or 3 to 4 hours after a meal).
5. Regular follow-up of liver function during medication.
[Medicine for pregnant and lactating women]
Pregnant and lactating women use it with caution. Less than 0.05% of the dose is excreted into breast milk. Although it has been reported that it has little effect on the baby, it is still necessary to consider whether to stop breastfeeding.
【Children's Medication】
The experiment has not been carried out and there is no reliable reference.
【Medications for the Elderly】
If there is no significant change in the pharmacokinetics of the elderly, there is no need to adjust the dose.
【medicine interactions】
1. Not compatible with ergotamine, dihydroergotamine, bromocriptine, terfenadine, ketoconazole and cisapride.
2. It has little effect on the metabolism of aminophylline, and basically has no effect on carbamazepine, warfarin, ranitidine and other antacids.
【Overdose】
The experiment has not been carried out and there is no reliable reference.
【Pharmacology and Toxicology】
This product is a semi-synthetic 14-membered ring macrolide antibiotic. The antibacterial spectrum and antibacterial effect are basically similar to those of erythromycin. The effect on gram-positive bacteria is slightly worse than that of erythromycin, and the effect on Legionella pneumophila is stronger than that of erythromycin. The antimicrobial effect of Chlamydia pneumoniae, Mycoplasma pneumoniae and Ureaplasma urealyticum is similar to or slightly stronger than that of erythromycin.
This product can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor ("P" position), blocking the binding of transfer ribonucleic acid (t-RNA) to the "P" position. It also blocks the transfer of the polypeptide chain from the acceptor position ("A" position) to the "P" position, thus inhibiting bacterial protein synthesis.
【Pharmacokinetics】
Oral absorption is good, and the peak plasma concentration (Cmax) is high. The peak plasma concentration (Cmax) of 6.6~7.9 mg/L can be reached about 2 hours after a single dose of 150 mg of roxithromycin. Eating can reduce the bioavailability by about half . It is widely distributed, and the drug concentration in tonsils, sinuses, middle ears, lungs, sputum, prostate and other urogenital tract tissues can reach effective therapeutic levels. Its protein binding rate is 96% at a blood concentration of 2.5 mg/L. It is excreted from the body in its original form and 5 metabolites, and 7.4% is excreted in urine. The blood elimination half-life (t1/2β) is 8.4 to 15.5 hours.
【Storage】
Shade, seal, and store in a dry place.
【package】
Aluminum-plastic blister packaging, 12 tablets/plate; carton packaging, 1 plate/box.
【Validity Period】
24 months
【Executive Standard】
"Chinese Pharmacopoeia" 2015 Edition Two
【Approval Number】
National Medicine Standard H10890050
【manufacturer】
Company Name: Shenyang Hongqi Pharmaceutical Co., Ltd. 
Production address: No. 6, Xinluo Street, Hunnan New District, Shenyang City      
Postal Code: 110179 
Phone number: (024) 23786260 23786261    
Fax number: (024) 23786263 
Website: www.hongqipharma.com
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