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  • Name: Pyrazinamide Tablets(0.25g)
  • Add time: 2015-05-15
  • Views : 67

Ingredient
Chemical Name: pyrazine carboxamide
Chemical Structure:
[Character]
White or white film category.
Indications
This product is only effective Mycobacterium, and other anti-TB drugs (such as streptomycin, isoniazid, rifampicin and ethambutol) combined for the treatment of tuberculosis.
[Specification]
0.25g
Dosage
Oral. The usual dose for adults, and other anti-TB drugs, the daily 15 ~ 30mg / kg Dayton clothing, or 50 ~ 70mg / kg, 2 or 3 times a week; daily use by the maximum daily 2g, up to 3 times in a week Every 3g, 2 times per week to a maximum per 4g.
Adverse reactions
A higher incidence of persons: joint pain (due to hyperuricemia caused, often mild, self-limiting); incidence is less: loss of appetite, fever, fatigue or weakness, yellowing of the eyes or skin (liver toxicity) , chills.
Taboo
Not to proceed with the experiment and no reliable references.
[Precautions]
(1) cross-allergy, similar to B isonicotinoyl amine, isoniazid, nicotinic acid or other chemical structure of drug allergy patients may have allergies to the chemicals.
(2) interfere with the diagnosis: It can be used to produce hydrogen cyanide and nitro red-brown, affect the measurement results ketone; can alanine aminotransferase, aspartate aminotransferase, increased blood uric acid concentrations were measured value .
(3) diabetes, gout or severe liver dysfunction with caution.
(4) should be using this medication often increased uric acid in the blood, can cause acute gout, serum uric acid should be performed.
(5) This product can also use intermittent dosing method, medication 2 times a week, each 50mg / kg.
[Pregnant women and lactating women drug]
TB patients can be pregnant with isoniazid, rifampicin and ethambutol 9 months of treatment, such as any of the above drug resistance while the product may be considered sensitive goods. This product is FDA pregnancy drug class C.
Pediatric Use
This product is a high toxicity, children should not be applied. After the decision must be weighed against the application.
[Geriatric medicine]
Not to proceed with the experiment and no reliable references.
Drug interactions
(1) The goods and allopurinol, colchicine, probenecid, sulfinpyrazone combined to increase serum uric acid concentration and reduce the efficacy of these drugs for gout. Therefore, dose adjustment should be combined in order to control hyperuricemia and gout.
(2) and B sulfur can enhance the adverse reactions when combined isonicotinoyl amine.
(3) with the use of cyclosporine and pyrazinamide may reduce the blood concentration of the former, and therefore need to monitor blood levels to adjust the dose accordingly.
Overdosage
Not to proceed with the experiment and no reliable references.
Pharmacology and Toxicology
The product of the human type Mycobacterium tuberculosis has a good antibacterial effect, in pH5 ~ 5.5, the sterilization of the strongest, especially in the slow growth in the acidic environment of phagocytes is the best sterilization TB drugs. This product is in vivo inhibitory concentration 12.5μg / ml, up to 50μg / ml can kill Mycobacterium tuberculosis. The product inhibition of the intracellular concentration of Mycobacterium tuberculosis in the extracellular lower than 10 times, almost no inhibitory effect in neutral and alkaline environment. The mechanism may be related to the pyrazine acid, pyrazinamide infiltrated into phagocytic cells and Mycobacterium tuberculosis bacteria enter the body, the bacteria in vivo lactamase it deamidated, pyrazine acid into play antibacterial effect. Another result of pyrazinamide similar in chemical structure and nicotinamide, substituted by interference dehydrogenase and nicotinamide, to prevent dehydrogenation, Mycobacterium tuberculosis to prevent oxygen utilization, while affecting the normal metabolism of the bacteria, resulting in death.
Pharmacokinetics
Rapidly and completely absorbed after oral administration in the gastrointestinal tract. Widely distributed in body tissues and fluids, including liver, lung, cerebrospinal fluid, kidney and bile. Cerebrospinal fluid drug concentrations up blood concentration of 87% to 105%. Protein binding rate of about 10% to 20%. 2 hours after oral administration up to the peak plasma concentration, t1 / 2 of 9 to 10 hours, liver, renal dysfunction may be extended. Mainly metabolized in the liver, hydrolyzed to the pyrazine acid as a metabolite with antibacterial activity, followed by hydroxylation into inactive metabolites excreted by glomerular filtration. Within 24 hours of metabolites from 70% (of which the pyrazine acid about 33%), 3% of the prototype discharge. 4 hours of hemodialysis can reduce blood concentration of 55% pyrazinamide, blood pyrazine acid reduced by 50% to 60%.
[Storage]
Shading, sealed and stored.
[Packaging]
Plastic bottles, 100 / bottle.
[Validity]
36 months
[Executive standard]
"Chinese Pharmacopoeia" 2010 edition Third Supplement
Approval Number
Zhunzi H21022354
Manufacturer
Company Name: Shenyang Hongqi Pharmaceutical Co., Ltd.
Production Address: Shenyang Hunnan New District envelope 6th Street
Postal Code: 110179
Phone Number: (024) 2,378,626,023,786,261
Fax: (024) 23786263
Website: www.hongqipharma.com

 

The above is for reference
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