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  • Name: Protionamide Enteric-coated Tablets
  • Add time: 2015-05-15
  • Views : 83

 

Ingredient
Chemical Name: 2-propyl thioisonicotinamide
Chemical Structure:
[Character]
This product is enteric-coated tablets, remove the coating, which was yellow.
Indications
This product is only effective mycobacteria, the product used in combination with other anti-TB drugs through the first-line TB drugs (such as streptomycin, isoniazid, rifampicin and ethambutol) treatment ineffective.
[Specification]
0.1g
Dosage
1. Adult usual dose: orally, in combination with other anti-TB drugs, once 250mg, day 2 or 3 times.
2. Pediatric usual dose: Unlike other anti-TB drugs, once according to body weight orally 4 ~ 5mg / kg, three times a day.
Adverse reactions
1. The higher incidence are: mental depression (CNS toxicity).
2. The incidence of those who have less: unsteady gait or numbness, tingling, burning sensation, foot pain (peripheral neuropathy), insanity or other mental changes (central nervous system toxicity), yellowing of the eyes or skin ( jaundice, hepatitis).
3. The incidence of very few who are: blurred vision or vision loss, associated or not with eye pain (optic neuritis), menstrual disorders or chills, loss of libido (men), dry and rough skin, thyroid dysfunction, joint pain, stiff swelling.
The continued occurrence of the following cases should be noted: diarrhea, increased saliva, drooling, loss of appetite, mouth, metallic taste, nausea, mouth pain, stomach pain, upset stomach, vomiting (gastrointestinal disorders, central nervous system toxicity) , dizziness (including when you get up from a lying or sitting position), lethargy, weakness (central nervous system toxicity).
Taboo
Not to proceed with the experiment and no reliable references.
[Precautions]
1. Cross-allergic patients isoniazid, pyrazinamide, nicotinic acid or other similar chemical structure of the drug allergy may be allergic to the chemicals.
2. The diagnosis of interference: can alanine aminotransferase, aspartate aminotransferase increased measured values.
3. have the following caution: diabetes, severe liver dysfunction.
The test shall be conducted during treatment: alanine aminotransferase, aspartate aminotransferase medication and treatment before ① measured every 2 to 4 weeks, but not necessarily indicative of said test values ​​increased occurrence of clinical hepatitis, and may be Continue treatment during regeneration; ② eye examination, such as during the treatment should be vision loss or other symptoms of optic neuritis eye examination immediately, and regularly reviewed.
[Pregnant women and lactating women drug]
Pregnant ban clothing.
Pediatric Use
Children under 12 should not take.
[Geriatric medicine]
Not to proceed with the experiment and no reliable references.
Drug interactions
1. and cycloserine same service allows an increased incidence of central nervous system reactions, especially convulsions symptoms. The dose should be adjusted and close monitoring of the central nervous system toxicity.
2. This product and other anti-TB drugs may increase the adverse reactions.
3. This product is a vitamin B6 antagonist, increase its renal excretion. Therefore, patients receiving prothionamide amine treatment, vitamin B6 requirements may increase.
Overdosage
Not to proceed with the experiment and no reliable references.
Pharmacology and Toxicology
This product is a derivative of isonicotinic acid, and its mechanism is unknown, may inhibit the synthesis of peptides. This product is the role of M. tuberculosis drug concentration depends on the site of infection, with only a low concentration inhibitory effect, high concentrations has a bactericidal effect. Inhibition of Mycobacterium tuberculosis mycolic acid synthesis. The goods and ethyl amine isonicotinoyl some cross-resistance phenomenon.
Pharmacokinetics
Rapid oral absorption (80%), widely distributed in body tissue fluid in various tissues and in cerebrospinal fluid and plasma concentration concentration approaching the same period. You can cross the placental barrier. Protein binding rate of about 10%. 1 to 3 hours after taking the drug concentration in the blood up to the peak, the effective blood concentration of sustainable six hours, t1 / 2 for about three hours. Mainly in the liver metabolism. By renal excretion, 1% for the prototype, 5% of the active metabolite, the rest are inactive metabolites.
[Storage]
Shading, sealed and stored.
[Packaging]
Plastic bottles, 100 / bottle.
[Validity]
36 months
[Executive standard]
"Chinese Pharmacopoeia" 2010 version of the first Supplements
Approval Number
Zhunzi H21022339
Manufacturer
Company Name: Shenyang Hongqi Pharmaceutical Co., Ltd.
Production Address: Shenyang Hunnan new network on the 6th Street Postcode: 110179
Phone Number: (024) 2,378,626,023,786,261 Fax: (024) 23786263

 

The above is for reference
If you have questions can contact the manufacturer