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  • Name: Gentamycin Sulfate and Bismuth Subcarbonate Capsules(10)
  • Add time: 2015-05-15
  • Views : 227

 

[Drug Name]
Generic Name:硫酸庆大霉素碳酸铋胶囊
English name:Gentamycin Sulfate and Bismuth Subcarbonate Capsules
Pinyin:Liusuan Qingdameisu Tansuanbi Jiaonang
Ingredient
This product is compound, the group were as follows: each containing gentamicin sulfate (with gentamicin meter) 0.04g (4 million units) and bismuth subcarbonate 0.6g.
[Character]
The contents of the product as a white to slight yellow powder or granules.
Indications
For chronic ulcerative colitis, diarrhea, acute enteritis.
[Specification]
Gentamicin sulfate 40mg, bismuth subcarbonate 0.6g.
Dosage
Oral.
An adult from 2 to 3, 3 times a day; once a child three times a day. Continuous medication, a spa
Cheng should not exceed 10 days.
Adverse reactions
1. rare nausea, loss of appetite, vomiting, abdominal distension and other gastrointestinal symptoms and rash, serum aminotransferase and so on.
2. Occasionally hearing loss, tinnitus or ear satiety (ototoxicity), hematuria, a significant reduction in the frequency of urination or decreased urine output, loss of appetite, extreme thirst (renal toxicity), gait disturbance, dizziness (ototoxicity, affecting vestibule), difficulty breathing, sleepiness, extreme weakness (nerve - muscle block).
3. The high-dose long-term use can cause constipation, alkalemia and malabsorption syndromes.
Taboo
The prohibited goods or other aminoglycoside antibiotic allergies.
[Precautions]
1. dehydration, 8th cranial nerve damage, myasthenia gravis or Parkinson's disease, kidney dysfunction in patients with caution.
2. patients allergic to other aminoglycoside antibiotics such as streptomycin, amikacin, etc., may also be allergic to the product.
3. bacteria resistant to other aminoglycoside antibiotics such as tobramycin, sisomicin, etc., are also likely resistant to the chemicals.
4. Long-term or chronic intestinal high-dose using the infected patients should pay attention to renal toxicity or ototoxicity possible.
5. Long-term or high-dose using appropriate regular urine, kidney function, hearing tests or hearing electroretinogram measurement.
6. Long-term blindness may lead to intestinal flora disturbance.
[Pregnant women and lactating women drug]
As the product is absorbed partially through the placenta into the fetal circulation, so pregnant women should be used with caution. During lactation breast-feeding should be suspended.
Pediatric Use
Because this product has the potential ototoxicity and nephrotoxicity, so children with caution.
[Geriatric medicine]
Because this product has the potential ototoxicity and nephrotoxicity, it is used with caution in elderly patients.
Drug interactions
1. and other aminoglycosides or has a continuous application, the possibility of toxicity, kidney toxicity and neuromuscular blockade may increase ear. And neuromuscular blocking drugs, may increase the neuromuscular blockade.
2. capreomycin, cisplatin, ethacrynic acid, furosemide plug microphone or vancomycin in combination or successively continuous application, increase the likelihood of ototoxicity and nephrotoxicity.
3. Cefalotin combination may increase renal toxicity.
4. combined with polymyxin class or has a continuous application, increase the renal toxicity and neuromuscular blockade.
5. Other nephrotoxic and ototoxic drugs are not combined with the goods or has a continuous application, so as not to aggravate the nephrotoxicity or ototoxicity.
6. With the large amount of fake anti-fungus unicellular fungus Penicillium (carbenicillin, ticarcillin, mezlocillin, azlocillin, piperacillin) allows inactivation of gentamicin, should be separately medication.
Overdosage
It is not clear.
Pharmacology and Toxicology
Aminoglycosides gentamicin sulfate, a variety of gram-negative bacteria and gram-positive bacteria have good antibacterial effect on all kinds of Enterobacteriaceae such as Escherichia coli, Klebsiella, deformation spp, Salmonella, Shigella, Enterobacter, Serratia and Pseudomonas aeruginosa have a good effect. Neisseria and Haemophilus influenzae moderately sensitive to the chemicals. Of the genus Brucella, Yersinia pestis, Acinetobacter spp., Campylobacter fetus also has a role. Staphylococcus (including Staphylococcus aureus and coagulase-negative staphylococci) and methicillin-sensitive strains of about 80% have a good antibacterial effect, but methicillin-resistant strains of the most resistant to the chemicals. Streptococcus and Streptococcus pneumoniae role of poor, Enterococcus is mostly resistant to the chemicals. This product in combination with β- lactams, the majority of available synergistic antibacterial effect. Its mechanism of action is the bacterial 30S ribosomal subunit, inhibiting bacterial protein synthesis. In recent years, Gram-negative bacteria to gentamicin resistant strains have increased significantly.
Basic bismuth in the gastrointestinal mucosa from the acid and astringent protective, by reducing intestinal irritation and reach antidiarrheal effect, to prevent dehydration and excessive body water and salt metabolism disorders.
Pharmacokinetics
Gentamicin sulfate oral absorption rarely reaches high concentrations in the gastrointestinal tract, mainly in the prototype with the feces. When the acute phase of diarrhea or intestinal inflammation or extensive ulcerative lesions, oral absorption can be increased. The product is absorbed very little portion of serum protein binding, mainly distributed in the extracellular fluid, but also through the placenta into the fetal circulation, but not easily through the blood - brain barrier, is not metabolized in the body, mainly by glomerular filtration discharge . Only trace amounts of bismuth basic carbonate oral absorption, is not metabolized, and excreted.
[Storage]
Shading, sealed and stored in a dry place.
[Packaging]
1, blister packaging, 10 / plate; carton packaging, a board / box.
2, blister packaging, 12 / plate; carton packaging, a board / box.
[Validity]
24 months
[Executive standard]
State Food and Drug Administration National Drug Standards WS-10001- (HD-0525) -2002-2007
Approval Number
Zhunzi H21023412
Manufacturer
Company Name: Shenyang Hongqi Pharmaceutical Co., Ltd.
Production Address: Shenyang Hunnan New District envelope 6th Street
Postal Code: 110179
Telephone: 024-23786260 23786261
Fax: 024-23786263

 

The above is for reference
If you have questions can contact the manufacturer