keyword :
分类
Products
  • Name: Praziquantel Tablets
  • Add time: 2015-05-14
  • Views : 83

[Drug Name]
Generic Name:吡喹酮片
English name:Praziquantel Tablets
Pinyin:Bikuitonɡ Piɑn
Ingredient
The main ingredients of praziquantel.
Chemical name: 2- (cyclohexyl carbonyl) -1,2,3,6,7,11b- hexahydro -4H- pyrazino [2,1-α] isoquinolin-4-one
Chemical Structure:
[Character]
White tablets.
Indications for the broad-spectrum anti flukes and tapeworms drugs. For a variety of schistosomiasis, clonorchiasis, paragonimiasis, fasciolopsiasis and taeniasis and cysticercosis
[Specification]
0.2g
[Dosage]
1. Treatment trematodes
① schistosomiasis: a variety of chronic schistosomiasis using a total dose of 60mg / kg for 1 to 2 days therapy, the daily amount divided between 2 to 3 times meal service. Acute schistosomiasis total dose 120mg / kg, the daily amount of 2 to 3 times, and even served on the 4th. Weighing more than 60kg are calculated according to 60kg.
② clonorchiasis disease: total dose of 210mg / kg, 3 times a day, even for 3 days.
③ paragonimiasis: 25mg / kg, 3 times a day, even for 3 days.
④ fasciolopsiasis: 15mg / kg, Dayton clothing.
2. Treatment of taeniasis
① beef and pork taeniasis: 10mg / kg, the morning Dayton clothing, one hour after taking magnesium sulfate.
② short Hymenolepis and Diphyllobothrium taeniasis: 25mg / kg, Dayton clothing.
3. The total dose of ill treatment of cysticercosis 120 ~ 180mg / kg, 3 to 5 days service, daily 2 to 3 times the amount of clothing.
[Adverse reactions]
1. The common side effects are dizziness, headache, nausea, abdominal pain, diarrhea, fatigue, aching limbs, etc., usually to a lesser extent, short duration, does not affect the treatment, without treatment.
2. The small number of cases of heart palpitations, chest tightness and other symptoms, ECG showed T wave changes and outside of contraction, the occasional supraventricular tachycardia, atrial fibrillation.
3. The small number of cases, there may be a transient increase in transaminases.
4. even can induce mental disorders or gastrointestinal bleeding.
Taboo
Eye cysticercosis patients disabled.
[Precautions]
1. Treatment of parasites in the tissue parasites such as schistosomiasis, lung fluke, cysticercosis, the parasite is killed since the release of large amounts of antigenic material, can cause fever, eosinophilia, rash, even can cause anaphylactic shock, must observe.
2. cerebral cysticercosis patients require hospitalization, and supplemented Prevention of cerebral edema and reduce the high intracranial pressure (dexamethasone and dehydrating agent) or treatment measures to control status epilepticus, to prevent accidents.
3. Merge eye cysticercosis, must first surgical removal of the worm, then drug treatment.
4. serious heart, liver, kidney patients and psychiatric history with caution.
5. There are obvious dizziness, drowsiness and other neurologic responders, during treatment and within 24 hours after discontinuation Do not be driving, operating machinery and other work.
6. rid Taenia cysticercosis, the need should be the exception recessive neurocysticercosis, to avoid accidents.
[Pregnant women and lactating women drug]
Lactating women during the medication until after stopping breastfeeding should not be within 72 hours.
Pediatric Use
Not to proceed with the experiment and no reliable references.
[Geriatric medicine]
Not to proceed with the experiment and no reliable references.
Drug interactions
Not to proceed with the experiment and no reliable references.
Overdosage
Not to proceed with the experiment and no reliable references.
Pharmacology and Toxicology
This product is effective against schistosomiasis, tapeworm, cysticercosis, clonorchiasis, lung fluke, ginger insects. Parasites can play on two main pharmacological effects:
The parasites produce spastic paralysis 1. muscle tonic contraction occurred. Schistosoma praziquantel after exposure to low concentrations of parasites tension that is only 20 seconds increased concentration of 1mg / L or more, the parasite quickly became intense contracture. Parasites and praziquantel muscle contraction may increase the permeability of the parasite cell membranes, intracellular calcium loss related.
2. The parasites damage the cortex involved in host immune function: praziquantel against parasites cortex rapid and significant injury caused syncytial vitro skin swelling, vacuoles, formed bleb, protruding surface, eventually skin ulceration erosion secreted body almost entirely disappeared, circular muscle and longitudinal muscle has also rapidly dissolved. In the host body, you can see the worms skin degeneration 15 minutes after taking the drug. After skin damage, affecting the parasite absorption and excretion function, and more importantly, its surface antigen exposure, thus vulnerable to host immune attack, a large number of eosinophils attachment skin lesions and invasive, prompting parasites died. In addition, praziquantel can cause secondary changes that parasite surface membrane depolarization, cortex alkaline phosphatase activity was significantly reduced, resulting in glucose uptake was inhibited, endogenous glycogen depletion. Praziquantel may also inhibit the synthesis of nucleic acids and proteins parasites.
[Pharmacokinetics]
Rapidly absorbed after oral administration, more than 80% of the drug can be absorbed from the gut. Plasma peak at about one hour to arrive soon after the metabolism of drugs into the liver, the main form hydroxy metabolites, only a very small amount of unmetabolized original drug into the systemic circulation. Portal vein blood drug concentration than the surrounding high concentrations more than 10 times. Cerebrospinal fluid concentrations of about 15% to 20% of the blood concentration of the medication in patients after lactation, the milk serum drug concentrations equivalent to 25%. Peak plasma oral 10 ~ 15mg / kg after approximately 1mg / L. The drug mainly in the liver, followed by kidney, lung, pancreas, adrenal, pituitary, salivary glands, rarely through the placenta, no organ-specific accumulation phenomenon. Half-life (t1 / 2) of 0.8 to 1.5 hours, the half-life of its metabolite (t1 / 2) is 4 to 5 hours. Mainly in the form of metabolites excreted by the kidneys, 72% within 24 hours of discharge, 80% in 4 days of discharge.
[Storage]
Shading, sealed and stored.
[Packaging]
Blister packaging, 18 / board, carton packaging, 2 plates / box;
Blister packaging, 36 / board, carton packaging, 10 plates / box;
Plastic bottles, 100 / bottle, carton packaging, 1 bottle / box;
Plastic bottles, 1,000 / bottle.
[Validity]
24 months
[Executive standard]
"Chinese Pharmacopoeia" 2010 edition two
[Approval Number]
Zhunzi H20093670
[manufacturer]
Company Name: Shenyang Hongqi Pharmaceutical Co., Ltd.
Production Address: Shenyang Hunnan New District envelope Street on the 6th
Postal Code: 110179
Phone Number: (024) 2,378,626,023,786,261
Fax: (024) 23786263

 

The above is for reference
If you have questions can contact the manufacturer